Evaluation of some individual antioxidants in seminal plasma of fertile & infertile men.

Abstract

(2000) Summary:
(2001) Background: infertility is defined as the inability of a couple to conceive after one year of a regular unprotected intercourse with the same partner. Many factors seem to play a role in male infertility.
(2002) Aim: to evaluate the role of some seminal plasma biochemical components in male infertility.
(2003) Methods: seminal plasma of 100 infertile men & 25 fertile men were chosen as a subject of this study.
(2004) Different biochemical parameters that are related to oxidative stress were measured. These included Glutathione Peroxidase (GSHPX),superoxide dismutase (SOD),cerulopasmin (CP) scavenging activity, albumin & total sulfhydral (T-SH) & its individual parts (protein & non protein binding sulfhydral (PB-SH & NP-SH)).
(2005) Results:- a significant decrease in GSHPX activity (P<0.05) , T-SH level (P<0.05), BP- SH (P<0.05) & SOD scavenging activity (P<0.01) was observed in infertile men in comparsion to that in the control group. While no significant differences were obsei-ved in albumin & CP scavenging activity between the two studies groups.
(2006) Conclusion:- the result of this study indicate the presence of imbalance between pro/antioxidant, which in turn lead to increase in the production of reactive oxygen species in seminal plasma & ultimately cause defect in sperm