Dyslipidemia and CA15-3 serum level in Iraqi Women with Breast Tumor: A Comparative Study

Abstract

Background: Lipids seem to have a direct influence in women breast cancer (BC) or dyslipidemia may be a consequence of this cancer.

Objective: the aim of this study is to define serum levels of lipid profile in women with breast cancer (BC) and to compare that with fibroadenoma benign breast tumor. Also, to assess the role of serum CA 15-3 in early diagnosis of breast cancer (BC).   
Patients and Methods: This case study was carried out at Biochemistry Department, College of Medicine, University of Baghdad, during the period from February 2017 to November 2017. It included 38 Iraqi women diagnosed with primary breast cancer (BC, Group-I) and 25 women with Fibroadenoma of benign breast tumor (FA, Group-II). Women with BC were sub divided according to their stage of BC into: stage I (n=12), stage II (n=14), and stage III (n=12). Investigations included serum measurements of CA 15-3 and lipid profile (Total Cholesterol, Triglyceride, LDL-Cholesterol and HDL-Cholesterol).

Results: The mean value of CA15-3 in breast cancer women was found to be significantly higher (p<0.001) as compared to benign group. The mean values of serum levels of TC, TG and LDL-C in breast cancer women were found to be significantly higher as compared to the benign women group (for all, p=0.001).

Conclusion: This study concluded that breast cancer was more associated with dyslipidemia than FA benign tumor.