Serum Leptin levels in ovarian polycystic disease and its correlation to body weight

Abstract

Background: Poly cystic ovary syndrome is a common disorder in women of  reproductive  age,  it  is associated  with  disturbance of  reproductive, endocrine  and  metabolic  functions. The pathophysiology of PCOS appears to be multifactorial and polygenic. Leptin seems to play an important role in pathophysiology of PCOS especially in women with BMI ≥25kg/m².  

J Fac Med Baghdad

2014; Vol.56, No .2

Received Sept .2013

Accepted April. 2014

Objectives:  To assess leptin level in both PCOS and healthy women and explore the relation to their body weight and body mass index.

Patient and Methods: A total of 120 women were enrolled in this study, 60 women (50%) had PCOS (study group) and the reminder 60 women (50%) were healthy women and considered as control group. BMI was calculated first. Both groups were further subdivided into two groups; BMI of ≥25kg/m² and BMI of <25kg/m². Pelvic U/S scan was done to confirm the diagnosis.

Hormonal profile (FSH, LH, LH/FSH, testosterone, TSH, T4 and prolactin) were measured. RBS was measured. Serum  leptin  level was  measured  in patient  with  PCOS  and  the  control   by  Enzyme  linked immunesorbant  assay (ELISA) test. Correlations between leptin levels and age, Wt, Ht, BMI, and serum hormone levels (FSH, LH, testosterone and prolactin) were studied.               

Results: Mean serum leptin levels were not significantly higher in patients with PCOS compared to the control group (P =0.052). Leptin levels were found to be higher significantly in the overweight subgroups both in patients with PCOS and in the control women. Leptin levels were found to be higher in over weight patients with PCOS compared to over weight control P value =0.0001. Serum  leptin  levels were  significantly correlated  with  BMI  in  both  patient  with  PCOS  and  control  group (r=0.918 and r=0.846)  respectively. Serum  leptin  concentration  had  a positive  correlation  with  serum  LH  concentration  in  PCOS  group (r=0.327). Leptin levels had strong positive correlation with serum LH, FSH, and testosterone in over weight PCOS subgroup women   and (r=0.592, 0.609 and 0.604) respectively. 

Conclusion: Leptin levels are higher in patient with PCOS compared to control groups. Leptin levels were correlated with the amount of fatty tissue not only in PCOS group but also in healthy women. Leptin play an important role in pathophysiology of PCOS of women with BMI ≥25 kg/m².