The In Situ Hybridization Expression of Fas and Fas Ligand (FasL) in Trophoblastic tissue of Aborted Women Compared with Normal Pregnancy.

  • Amal H. Salman Dept. of Community Medicine, Technical Collage of Health and Medicine.
  • Dalya B. Hana Dept.of Medical Microbiology & Biotechnology, College of Pharmacy, University of Mustansiriya.
  • Dhamraa W. Ahmad Dept. of Clinical Laboratory Science, Technical Collage of Health and Medicine
DOI: https://doi.org/10.32007/1215%25g211-215
Keywords: Fas and Fas-Ligand in trophoblasts, In Situ Hybridization.

Abstract

Background: Estimation of the in situ expression of Fas and Fas ligand (FasL) in aborted women compared with normal human pregnancy .
Patients and Methods: A technique utilizing in situ hybridization(ISH) was performed to detect and determine the in situ expression of Fas and Fas ligand (FasL) mRNA using paraffin embedded sections of curettage samples obtained from 42 women, who were divided into two groups: 30 women with first trimester abortion and 12 women with induced abortion as control.
Results: The levels of the in situ expression of both Fas and Fas ligand (FasL) mRNA were found to be highly significant increased in group 1 as compared with group 2
(p<0.01), with a significant positive correlation between Fas; and abortion in group I , FasL & abortion in group I , and between these two parameters(Fas & FasL) (p<0.01) in group1 .
Conclusions: The increasing expression of Fas and FasL trophoblasts might influence pathogenesis of first trimester abortion.

Downloads

Download data is not yet available.
Published
2009-07-01
How to Cite
1.
Salman A, Hana D, Ahmad D. The In Situ Hybridization Expression of Fas and Fas Ligand (FasL) in Trophoblastic tissue of Aborted Women Compared with Normal Pregnancy. J Fac Med Bagdad [Internet]. 1Jul.2009 [cited 21Nov.2019];51(2):211-5. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1215
Issue
Vol 51 No 2 (2009): Journal of the Faculty of Medicine Baghdad
Section
Articles

 For all articles published in Journal of the Faculty of Medicine Baghdad, copyright is retained by the authors. Articles are licensed under an open access Creative Commons CC BY NC 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. These conditions allow for maximum use and exposure of the work, while ensuring that the authors receive proper rights.