Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.

  • Sajid N. Abdualkader Teaching Laboratories, Medical city (Clinical Immunology.
  • Abdul- Wahab Al-Shaikly Dept. of Microbiology-Al-Kindi College of Medicine (Clinical Immunology)
  • Khalida M. Al-Mousawy Dept. of Microbiology-College of Medicine- University of Baghdad (Clinical Immunology)
  • Mustafa Al-Ezzi Rheumatology unit-Dept. of Medicine- University of Baghdad
  • Maan G. Hasso Teaching Laboratories, Medical city (Clinical Immunology.
  • Zena E. Hassan Dept. of Immunology, College of Medicine, Al-Yarmouk University.
DOI: https://doi.org/10.32007/jfacmedbagdad.v4416-418%25
Keywords: Autoantibodies, Interleukin-4, Interleukin-6, systemic lupus erythematosus

Abstract

Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE
Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only)
Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production.
Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients.

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Published
2010-01-03
How to Cite
1.
Abdualkader S, Wahab Al-Shaikly A-, Al-Mousawy K, Al-Ezzi M, Hasso M, Hassan Z. Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. J Fac Med Bagdad [Internet]. 3Jan.2010 [cited 30Nov.2019];51(4):416-8. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1097
Issue
Vol 51 No 4 (2009): Journal of the Faculty of Medicine Baghdad
Section
Articles

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